- Uric acid is a substance found in the blood that may contribute to certain chronic medical
conditions and disorders, such as diabetes, insulin resistance, and high blood pressure. High
uric acid concentrations have been associated with stroke and heart disease, as well as
chronic heart failure. In particular, researchers are interested in determining the
relationship between uric acid and inflammatory markers, or chemicals in the blood that can
indicate inflammation and other problems with the body.
- To study the specific effects of changes in uric acid in the body.
- To determine whether uric acid contributes to inflammation in the body.
- Healthy individuals between 50 and 75 years of age.
- This study will involve four visits: a screening visit, two study visits, and a followup
- At the screening visit, participants will have a physical examination, blood and urine
tests, and an electrocardiogram. Participants will be divided into two groups based on
the existing amount of uric acid in their blood.
- Within 7 days of the screening visit, participants will have a full-day study visit with
a magnetic resonance imaging scan, followed by a high-fat meal and further blood samples
collected over the following 8 hours.
- At least 2 days after the first study visit, participants will have the second study
visit, which will require a 2-night stay at the National Institutes of Health.
Participants will have a metabolism test, and will receive the following infusions based
on the groups they were assigned to at the screening visit.
- Group A (low uric acid) will receive either uric acid or a placebo.
- Group B (moderate to high uric acid) will receive either Rasburicase (a drug that
reduces the amount of uric acid in the blood) or a placebo.
- After the infusions and related blood tests, participants will have a high-fat meal with
further blood and urine samples.
- Approximately 2 weeks after the second study visit, participants will have a final
followup visit with additional blood and urine tests to determine whether the levels of
uric acid in the blood have returned to normal.