The investigators wish to examine whether a novel 'nanoparticle' of iron oxide, administered
intravenously allows an area of heart muscle damage after heart attack to be visualised using
a magnetic resonance scanner.
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Full eligibility criteria for NCT01323296
Ages eligible for Study
18 Years to 80 Years
Genders eligible for Study
Accepts Healthy Volunteers
Presentation with myocardial infarction (either 'ST-elevation' myocardial infarction or 'non-ST-elevation' myocardial infarction
Troponin I ≥ 10 IU/mL at 12 hours after the onset of chest pain
Age 18 - 80 years inclusive
Known critical (≥95%) left main stem coronary artery disease
Continued symptoms of angina at rest or minimal exertion
Symptomatic heart failure; Killip Class ≥2.
Hepatic failure (Childs-Pugh grade B or C) or renal failure (estimated glomerular filtration rate <25 mL/min)
Contraindication to magnetic resonance imaging
Past history of systemic iron overload/haemochromatosis
Patients with known allergy to dextran- or iron-containing compounds
All locations for NCT01323296
United Kingdom (2)
Royal Infirmary of Edinburgh
Edinburgh, Midlothian, United Kingdom, EH16 4SA
University of Edinburgh
Edinburgh, Midlothian, United Kingdom, EH16 4SU
View full eligibility
Tris trial is registered with FDA with number: NCT01323296. The sponsor of the trial is University of Edinburgh and it is looking for 15 volunteers for the current phase.
Official trial title: Ferumoxytol for Magnetic Resonance Imaging of Myocardial Infarction
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