The purpose of this study is to see if giving rifampin, a marketed antibiotic, changes how
your body absorbs and distributes BAY73-4506.
Drug: Regorafenib (BAY73-4506) + rifampin
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Locations near you
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Full eligibility criteria for NCT01322438
Ages eligible for Study
18 Years to 45 Years
Genders eligible for Study
Accepts Healthy Volunteers
Healthy male subject
Age: 18 to 45 years (inclusive) at the first screening examination / visit
Body mass index (BMI): 18 to 32 kg/m² (inclusive)
Ability to understand and follow study-related instructions
Subjects enrolled in this study must use adequate barrier birth control measures prior to, during the course of the study, and 3 months after the last administration of regorafenib. An adequate contraception includes the use of condoms or a vasectomy. In addition, adequate birth control measures for the subject's partner is required, such as a hormonal contraception with implants or combined oral contraceptives, certain intrauterine devices, bilateral tubal ligation, or hysterectomy.
Clinically significant disease or condition
Recent serious infection
All locations for NCT01322438
United States (1)
Austin, Texas, United States, 78744
View full eligibility
Tris trial is registered with FDA with number: NCT01322438. The sponsor of the trial is Bayer and it is looking for 24 volunteers for the current phase.
Official trial title: A Phase 1, Non-Randomized, Open Label Study to Determine the Effect of Rifampin on the Pharmacokinetics of a Single Oral Dose of 160 mg Regorafenib (BAY73-4506) in Healthy Volunteers
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