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Your journey
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More info
You can access this
clinical trial
if you have
Lymphoblastic Leukemia, Acute, Childhood, Myelogenous Leukemia, Acute, Childhood, Hodgkin's Disease or Non-Hodgkin's Lymphoma
and you are
between 8 and 21
years old
1
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

This study is for patients with relapsed or refractory Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML), Hodgkin's Disease (HD) or Non-Hodgkin's Lymphoma (NHL). Panobinostat is a new drug that is considered investigational because it has not been approved in the United States by the Food and Drug Administration (FDA), or in any other country. Panobinostat is a histone deacetylase inhibitor (HDACi) and interferes with gene expression found in cells causing them to stop growing or die. Panobinostat has been used in several hundred adults who had leukemia, HD, NHL and other solid tumors. Panobinostat has not been given to children. This is a phase I study. In a phase I study, drugs are tested to the highest dose that can be safely given. Drugs are given at gradually increasing dosages until there are unacceptable side effects. The goal of the Phase I study is to find out the dose of panobinostat that can be safely given to children with relapsed ALL, AML, HD and NHL.

Provided treatments

  • Drug: Panobinostat
  • Drug: Cytarabine
  • Drug: Panobinostat

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01321346. The sponsor of the trial is Therapeutic Advances in Childhood Leukemia Consortium and it is looking for 30 volunteers for the current phase.
Official trial title:
A Phase I Dose Finding Study Of Panobinostat In Children With Refractory Hematologic Malignancies