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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Renal Function, Endothelial Function, Blood Pressure, Overweight or Obesity
and you are
between 18 and 75
years old
This is a trial in the final phase before the treatment is released on the market.
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The purpose

The investigators hypothesize that, among non-hypertensive overweight and obese individuals, treatment of vitamin D deficiency and lowering uric acid concentrations (by either xanthine oxidase inhibition or increased renal excretion) will attenuate renin angiotensin system (RAS) activation, improve endothelial function, and lower blood pressure.

Provided treatments

  • Drug: Vitamin D ergocalciferol
  • Drug: Probenecid
  • Drug: Allopurinol
  • Drug: Placebo
  • Drug: Placebo

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01320722. The sponsor of the trial is Brigham and Women's Hospital and it is looking for 242 volunteers for the current phase.
Official trial title:
Modifiable Effectors of Renin System Activation: Treatment Evaluation (MODERATE)