Low blood pressure or hypotension is a very important problem that is often seen in premature
babies, especially those with low birth weight. Severe hypotension leads to significant
problems including brain bleeds, developmental delays, kidney and liver problems, and other
issues that can affect babies for the rest of their lives. An important aspect in the
management of infants with hypotension is the decision of when to treat and with what agent.
Research is being conducted to try to find the best medication to use in these situations.
Dopamine is often used first, but it does not always prove to be effective, and it has
several concerning side effects. This study will look at vasopressin, which has fewer side
effects, as a first-line medication for low blood pressure in extremely low birth weight
Hypotheses and Specific Aims: This study will show superiority of vasopressin to dopamine in
preterm, extremely low birth weight infants who have hypotension within the first 24 hours of
life. We will specifically look at its ability to raise blood pressure values, improve
clinical symptoms seen, any adverse effects, and clinical outcomes of babies being treated.