The purpose of this study is to assess the safety and efficacy of AL-54478 0.005% compared
with Latanoprost 0.005% and AL-54478 Vehicle in patients with open-angle glaucoma or ocular
Drug: AL-54478 0.005%
Drug: Latanoprost 0.005%
Drug: AL-54478 Vehicle
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Locations near you
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Full eligibility criteria for NCT01318252
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Patients diagnosed with either OAG or OHT.
Patients who are able to comply with the scheduled visits.
Patients who have had a physical exam within 6 months of the Screening Visit.
Other protocol-defined inclusion criteria may apply.
Females of childbearing potential who meet any 1 of the following conditions: a) Currently pregnant; b) Positive urine pregnancy test; c)Intend to become pregnant; d) Breast feeding; e) Not using highly effective birth control measures.
Patients with extreme narrow angle with complete or partial closure.
Patients with a cup to disc ratio more than 0.8.
Patients with a severe central visual field loss in either eye.
Patients with chronic or recurrent inflammatory eye disease or acute ocular infection or inflammation.
Patients who have had ocular trauma within the past 6 months or have had intraocular surgery within the past 6 months or have had ocular laser surgery within the past 3 months.
Patients with best-correct visual acuity less than 20/80.
Patients who have had ocular infection or inflammation within the past 3 months.
Patients who have clinically relevant progressive retinal disease.
Patients who have severe illness or conditions.
Patients who have hypersensitivity to a prostaglandin analogu.e
Patients who are unable to safely discontinue all IOP-lowering medications during washout.
Patients who are currently on therapy with another investigational agent within 30 days prior to the Screening Visit.
Other protocol-defined exclusion criteria may apply.
All locations for NCT01318252
United States (1)
Alcon Call Center
Fort Worth, Texas, United States, 76134
View full eligibility
Tris trial is registered with FDA with number: NCT01318252. The sponsor of the trial is Alcon Research and it is looking for 64 volunteers for the current phase.
Official trial title:
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