This prospective randomized study aims to determine whether intermittent pneumatic
compression (IPC), 75 patients, beneath functional bracing compared to treatment-as-usual in
plaster cast, 75 patients, can reduce the Venous Thromboembolism (VTE) incidence and promote
healing of sutured acute Achilles tendon ruptures.
At two weeks post surgery, the IPC intervention will be ended and both patient groups will be
immobilized in an orthosis until follow-up at six weeks.
The endpoint of the first part of the study is VTE events. The primary outcome will be the
DVT-incidence at two weeks, assessed using screening compression duplex ultrasound (CDU) by
two ultrasonographers masked to the treatment allocation. Secondary outcome will be the
DVT-incidence at 6 weeks.
1) Deep Vein Thrombosis (DVT) detected by CDU , 2) isolated calf muscle vein thrombosis
(ICMVT) detected by CDU, 3) symptomatic DVT or ICMVT detected by CDU, 4) symptomatic
pulmonary embolism detected by computer tomography.
The endpoint of the second part of the study is tendon healing quantified at 2 weeks by
microdialysis followed by quantification of markers for tendon repair.
The endpoint of the third part of the study is the functional outcome of the patients at one
year post-operatively using four reliable and valid scores, i.e. the Achilles tendon Total
Rupture Score (ATRS), Physical Activity scale (PAS), Foot and Ankle Outcome Score (FAOS) and
EuroQol Group's questionnaire (EQ-5D) as well as the validated heel-rise test.