Probiotics are favorable microorganisms that regulate the flora of the gastrointestinal
system and stimulate the immune system. Necrotizing enterocolitis incidence is 10-25% in
newborn infants whose birth weights are < 1500 gr. Although bifidobacterium and lactobacilli
sp. have been used to reduce the incidence of NEC in clinical trials, Saccharomyces boulardii
has not been used in the prevention of NEC in very low birth weight infants yet. The
objective of this study is to evaluate the efficacy of orally administered S boulardii in
reducing the incidence and severity of NEC in very low birth weight infants.