- Certain types of cancers, including sarcoma and melanoma, have specific antigens (protein
molecules) on their surfaces. Research has shown that producing an immune reaction to these
antigens may be able to keep tumors from growing by encouraging the immune system to destroy
the tumor cells. By creating a vaccine that contains antigens similar to those found on the
cancer cells, researchers hope to cause an immune reaction that targets the cancer cells.
However, more research is needed to determine the safety and effectiveness of this type of
- To determine whether a tumor cell vaccine, given to individuals who have had surgery to
remove malignant tumors from the chest, can cause an immune reaction that will prevent the
tumors from coming back.
- Individuals at least 18 years of age who have been diagnosed with cancer that has spread to
the lungs, pleura, or mediastinum, and have recently had surgery to remove tumors in the
- Participants will be screened with a physical examination and medical history, as well
as blood tests and imaging studies.
- Participants will have the option to have leukapheresis to collect white blood cells for
studies on how the body is responding to the vaccine. Participants who agree to have
this procedure will have it before the start of treatment and after the sixth and eighth
- Seven days before the first vaccine, participants will receive the chemotherapy drugs
celecoxib and cyclophosphamide to take twice a day at home.
- Participants will receive the experimental vaccine as an injection in the thigh or arm,
and may receive it in two shots depending on how many cells are in each vaccine.
Participants will receive a diary to monitor medication doses and side effects, as well
as additional cyclophosphamide and celecoxib to take at home as directed by the study.
- Participants will have one vaccine every month for 6 months, and will have regular blood
tests and imaging studies. After the sixth vaccine, participants who have successfully
responded to the treatment will have two additional vaccines given 3 months apart.
- After the eighth vaccine, participants will have followup visits every 3 months for 1
year and then every 6 months for up to 4 years....