- Medications to treat major depression act on a brain chemical called serotonin, which binds
to receptors on brain cells. More research is needed on how serotonin receptors work in the
brain, and imaging studies such as magnetic resonance imaging (MRI) can provide information
on how these receptors function in the brains of individuals with depression and healthy
volunteers. The experimental radioactive chemical [11C]CUMI has been designed to react with
serotonin receptors, and researchers are interested in studying its effectiveness using
positron emission tomography (PET) scanning to see how well it gets into the brain.
- To evaluate the effectiveness of the radiotracer [11C]CUMI in brain imaging studies of
- Individuals between 18 and 55 years of age who either have been diagnosed with major
depressive disorder or are healthy volunteers.
- Participants will be screened with a full medical history, physical and psychiatric
examination, blood and urine tests, and questionnaires about mood. Participants will
also have an electrocardiogram at this visit.
- At the first study visit, participants will have a MRI scan of the brain to provide
baseline data on brain function.
- At the second study visit, participants will have a PET scan with the [11C]CUMI contrast
- No treatment will be provided as part of this protocol....