Forty-eight people diagnosed with social phobia in an experimental study that randomized into
two treatment groups: 1) Internet-based Cognitive Behavioural Therapy (iCBT) (n = 24) or 2)
computerized attention training (n = 24). After nine weeks we change the condition of the two
groups of research participants, which should therefore be given both treatments. Pre-and
post measurement of functional magnetic resonance imaging (fMRI) will take place in the first
round of treatment. Genotyping based on saliva samples takes place before the start of
treatment, at the first fMRI measurement, for those who voluntarily leave the sample.
How is the brain activity of emotional processing and anxiety affected after completing an
Internet-based CBT compared with computerized attention training? Does the treatment response
of an Internet based treatment affects by variations in serotonin-transporter-linked promoter
region (5-HTTLPR) and tryptophan hydroxylase-3 (TPH3) genes?
How is the genetic variations related to symptoms in social phobia (pre treatment)?