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You can access this
clinical trial
if you have
Drug Interactions
and you are
between 18 and 60
years old
-
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

The aim of the present study is to assess the impact of CYP3A4-induction by SJW on steady state ambrisentan and the impact of the cytochrome P450 2C19 (CYP2C19) genotype (*2 and *3 allele vs. wild type; ~2-5% poor metabolisers in Caucasian population) on the pharmacokinetics of ambrisentan in healthy volunteers.

Provided treatments

  • Drug: St. Johns wort

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01311362. The sponsor of the trial is Gerd Mikus and it is looking for 20 volunteers for the current phase.
Official trial title:
Influence of CYP3A4-induction by St. John's Wort (SJW) on the Steady State Pharmacokinetics of Ambrisentan