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More info
You can access this
clinical trial
if you have
Drug Interactions
and you are
between 18 and 60
years old
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

The aim of the present study is to assess the impact of CYP3A4-induction by SJW on steady state ambrisentan and the impact of the cytochrome P450 2C19 (CYP2C19) genotype (*2 and *3 allele vs. wild type; ~2-5% poor metabolisers in Caucasian population) on the pharmacokinetics of ambrisentan in healthy volunteers.

Provided treatments

  • Drug: St. Johns wort

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01311362. The sponsor of the trial is Gerd Mikus and it is looking for 20 volunteers for the current phase.
Official trial title:
Influence of CYP3A4-induction by St. John's Wort (SJW) on the Steady State Pharmacokinetics of Ambrisentan