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Your journey
1What's a trial
4Get in touch
More info
You can access this
clinical trial
if you have
Rheumatoid Arthritis, Ankylosing Spondylitis or Psoriatic Arthritis
and you are
between 18 and 80
years old
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

Inflammatory arthritis particularly rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis are potentially disabling conditions which cause joint pain, swelling and deformity and treatments are aimed at preventing these complications. Although treatment has improved with the advent of antiTNFalpha therapies, up to 30% of patients fail to respond to this treatment and in others, treatment is associated with significant side effects. The precise mechanisms of this remain unclear. In addition, there are no sensitive methods available to monitor or predict disease response to treatment aside from testing inflammatory markers in the blood. Understanding the mechanism of action and what governs response to antiTNF therapy will allow development of more specific therapies for inflammatory arthritis. Work in animal models of rheumatoid arthritis has characterised a novel cell type, Th17 cells, important in the inflammatory cascade which are affected in a particular way by antiTNF therapies and may underpin their mechanism of action and side effects. We aim to translate these findings into patients with rheumatoid arthritis and other conditions treated with anti-TNF therapy, such as psoriatic arthritis and ankylosing spondylitis. Patients from rheumatology clinics within NHS trusts will be recruited. We will correlate disease activity assessed by clinical parameters, ultrasonography and questionnaires with biomarkers in the blood and target tissues, such as synovium and skin.

Provided treatments

  • Drug: anti-TNF therapy (etanercept or adalimumab)

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01060098. The sponsor of the trial is Imperial College London and it is looking for 52 volunteers for the current phase.
Official trial title:
T Cells and TNF: The Impact of TNF Blockade on Effector T Cell Populations in Rheumatoid Arthritis and Other Conditions Treated With Anti-TNFalpha Agents