To detect differences in MR spectroscopy, diffusion weighted MR, diffusion tensor imaging
(DTI) or dynamic contrast enhancement (DCE) MR imaging between primary cervical tumors and
normal cervical tissue.
Device: MR Spectroscopy
Device: Fat-Saturation and Diffusion-Weighted Imaging
Device: Dynamic Contrast Enhancement MRI (MR-DCE)
Device: Diffusion Tensor Imaging (DTI)
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Full eligibility criteria for NCT01060033
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Patients must have biopsy-proven newly diagnosed squamous cell cervical cancer (FIGO clinical stages IB2-IVA).
Patients must be ≥ 18 years of age.
Patients must be able to receive standard radiation therapy (external beam radiation and brachytherapy) with or without chemotherapy.
Patients with distant metastatic disease are eligible provided the estimated survival of the patient is at least one year.
Patients must be scheduled to undergo or have already undergone FDG-PET/CT imaging for clinical staging cervical cancer at Barnes-Jewish Hospital Clinical PET facility on the Siemens Biograph 40 True Point Tomograph Scanner or elsewhere in the WUSM Nuclear Medicine department using the quality controls instituted by Nuclear Medicine.
Patients must be able to give informed consent.
Patients with another known active malignancy.
Patients who have received treatment for any malignancy (with the exception of non-melanoma skin cancer) in the past 5 years.
Pregnant or breastfeeding patients.
Patients whose tumors are not FDG avid on baseline standard of care FDG-PET/CT imaging.
Patients with contraindications to MRI scanning.
All locations for NCT01060033
United States (1)
Washington University School of Medicine
St. Louis, Missouri, United States, 63110
View full eligibility
Tris trial is registered with FDA with number: NCT01060033. The sponsor of the trial is Washington University School of Medicine and it is looking for 9 volunteers for the current phase.
Official trial title: A Study of Novel Magnetic Resonance Imaging Sequences for Target Delineation and Prognostication in Cervical Cancer
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