The purpose of this study is to determine the maximum tolerated dose of the combination of
vorinostat, cisplatin, pemetrexed, and radiation therapy in patients with unresectable stage
IIIA/IIIB non-small cell lung cancer.
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Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT01059552
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
biopsy proven non-squamous NSCLC with unresectable stage IIIA or dry IIIB disease.
FEV1 >/= 1 liter
ECOG PS 0 or 1
Able to swallow and absorb enterally
Measurable disease per RECIST 1.1
Adequate organ and marrow function including calculated creatinine clearance >/= 60 mL/min hepatic enzymes and alk phos </= 2.5 X ULN.
Chemotherapy or radiotherapy </= 4 weeks prior to registration (6 weeks for nitrosureas)
Known brain mets
Prior thoracic radiotherapy that would lead to overlap with current radiation field.
More than 10% weight loss in 6 months.
Pancoast tumors, supraclavicular or contralateral hilar lymph node involvement
Known HIV positive
Prior treatment with an HDAC inhibitor
All locations for NCT01059552
United States (3)
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
View full eligibility
Tris trial is registered with FDA with number: NCT01059552. The sponsor of the trial is Fox Chase Cancer Center and it is looking for 18 volunteers for the current phase.
Official trial title: Phase I Study of the HDAC Inhibitor Vorinostat With Chemotherapy and Radiation Therapy for Treatment of Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
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