The purpose of this study is:
1. To assess the safety and feasibility of minocycline administration after TBI in a dose
escalation study at two different doses over 7 days.
2. To assess the pharmacokinetic characteristics of two different dosing regimens of
minocycline in TBI patients, the effect on biochemical markers of neuroprotective
mechanisms, and effect on neurobehavioral and functional outcome.
3. To begin initial assessment of the efficacy of minocycline as a therapeutic agent for
severe human TBI.