This is a pilot study of a protocol for inducing a falciparum malaria infection in healthy
volunteers in order to test the activity of novel agents being developed as drugs for the
treatment of uncomplicated malaria. In this pilot study, 16 healthy male volunteers will be
administered a low level malaria infection via infected human red blood cells. After 6 days
they will be administered one of two registered antimalarial treatments (8 volunteers for
each treatment) in order to define the rate of clearance of the infection. This information
will be used to design similar future studies for the initial assessment of the efficacy of
novel antimalarial drugs in development.