This is a prospective study of temporary gastric mucosal electrical stimulation (tGES) in 30
patients with gastroparesis (GP). After a 7 day baseline assessment of symptoms, subjects
will have an endoscopically-placed tGES lead implanted into the mucosa of the antrum. This
lead is connected to a thin wire that runs up the esophagus and out the nostril, similar to a
nasojejunal feeding tube, although much thinner. It is then attached to a programmable
battery pack which provides the desired level of stimulation.
Patients will then be randomized to 7 days OFF or 7 days ON stimulation in a double-blind
fashion. After 7 days, subjects will crossover to the other study arm (ie ON patients will be
switched off; OFF patients will be switched on). Symptoms and QoL measures will be assessed
at baseline, ON, and OFF periods. Serum ghrelin and other hormones, as well as EGG will be
assayed after 6 days in each arm.