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More info
You can access this
clinical trial
if you have
Iron Deficiency
and you are
between 18 and 45
years old
-
The phase for this study is not defined.
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The purpose

Several iron compounds are used for fortification, including ferrous sulphate and NaFeEDTA. The absorption profile of these may differ because of differences in their dissolution in the gastrointestinal tract and in their interaction with dietary inhibitors of iron absorption. As these differences might lead result in varying reactions in the blood stream, the appearance rate of the stable iron isotope, hepcidin, non-transferrin-bound iron and total iron in the plasma will be monitored over six hours in adult women. This is relevant as a spike of absorbed iron may increase non-transferrin-bound iron and this could be pro-oxidative or increase growth of pathogens. Hepcidin is a key mediator of iron absorption and will help explain the potential differences in the plasma iron profile. The use of stable iron isotope appearance curves to specifically detect the appearance of small amounts of absorbed iron in the blood and distinguish between circulating body iron and iron absorbed from the test meal was tested in a pilot study (EK 2008-23). This method is now used in a bigger sample to test the differences in absorption profile of ferrous sulphate, FePPi and NaFeEDTA given at fortification level with a meal.

Provided treatments

  • : Porridge fortified with either NaFeEDTA
  • : FeSO4

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01053442. The sponsor of the trial is Swiss Federal Institute of Technology and it is looking for 17 volunteers for the current phase.
Official trial title:
Absorption, Stable Isotope Appearance and NTBI Profile From NaFeEDTA and Ferrous Sulphate