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Your journey
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More info
You can access this
clinical trial
if you have
Symptomatic Carotid Stenosis, Hypercholesterolemia or Indication for Carotid Endarterectomy
and you are
between 50 and 85
years old
-
The phase for this study is not defined.
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The purpose

The impact on cardiovascular events achieved by statin therapy seems to be mostly attributable to the cholesterol-lowering effect with a highly debated contribution of the lipid-independent pleiotropic effects. However, a short-term benefit has been documented for patients treated with statins in acute coronary syndromes and other clinical settings. These observations strengthened the hypothesis of additional, so-called pleiotropic actions of statins. The investigators therefore sought to investigate how different lipid-lowering strategies (non-statin therapy, low-dose statin and high-dose statin) affects cellular composition of carotid plaque over a short-term period of three months. Specifically the investigators tried and dissect the LDL-C lowering impact on plaque cellular composition as compared to the lipid-independent contribution on plaque macrophage and smooth muscle cells.

Provided treatments

  • Drug: Atorvastatin - Cholestyramine - Sitosterol

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01053065. The sponsor of the trial is University of Padua and it is looking for 60 volunteers for the current phase.
Official trial title:
The Multicenter Atorvastatin Plaque Stabilization (MAPS) Study