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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Symptomatic Carotid Stenosis, Hypercholesterolemia or Indication for Carotid Endarterectomy
and you are
between 50 and 85
years old
The phase for this study is not defined.
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The purpose

The impact on cardiovascular events achieved by statin therapy seems to be mostly attributable to the cholesterol-lowering effect with a highly debated contribution of the lipid-independent pleiotropic effects. However, a short-term benefit has been documented for patients treated with statins in acute coronary syndromes and other clinical settings. These observations strengthened the hypothesis of additional, so-called pleiotropic actions of statins. The investigators therefore sought to investigate how different lipid-lowering strategies (non-statin therapy, low-dose statin and high-dose statin) affects cellular composition of carotid plaque over a short-term period of three months. Specifically the investigators tried and dissect the LDL-C lowering impact on plaque cellular composition as compared to the lipid-independent contribution on plaque macrophage and smooth muscle cells.

Provided treatments

  • Drug: Atorvastatin - Cholestyramine - Sitosterol

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01053065. The sponsor of the trial is University of Padova and it is looking for 60 volunteers for the current phase.
Official trial title:
The Multicenter Atorvastatin Plaque Stabilization (MAPS) Study