There are evidence that there is an association between insulin resistance and prolonged
hyperinsulinemia or hyperglycemia in Type 2 diabetic patients. This will trigger oxidative
stress system via reactive oxygen species (ROS) and lead to a high level of Nitric oxide.
This can contribute to a significant change in blood vessel and could end up with the
complications from cardiovascular disease and increased mortality rate of type 2 diabetic
patients. The purpose of the present study was to examine the effectiveness of the curcumin
in type 2 diabetic patients on the reduction of atherosclerosis events by examining
pulse-wave velocity (PWV) and plasma high-sensitivity C-reactive protein (CRP) test and on
blood sugar lowering, glycosylated hemoglobin (HBA1c), lipid profile, and insulin resistance.