This study will test whether a cognitive remediation program to treat people with
schizophrenia can be successfully implemented in a network of research clinics.
Behavioral: Targeted cognitive training
Behavioral: Computer control
Behavioral: Bridging groups
Behavioral: Health and wellness groups
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Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT00930150
Ages eligible for Study
18 Years to 55 Years
Genders eligible for Study
Accepts Healthy Volunteers
Demonstrates adequate decisional capacity to make a choice about participating in the research study
Diagnosis of schizophrenia or schizoaffective disorder, as defined by DSM-IV-TR criteria and confirmed by the Structured Clinical Interview for DSM-IV (SCID)
Positive and Negative Syndrome Scale (PANSS) hallucinatory behavior, unusual thought content, and conceptual disorganization ratings of no greater than moderately severe
(i.e., item scores must be less than or equal to 5)
Meets all of the following cognitive performance and English language criteria:
Learned English before age 12
Able to complete the baseline Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) validly, based on the judgment of the investigator
Raw score of 37 or greater on the Wide Range Achievement Test, reading subtest, 3rd edition (WRAT-3), used to establish minimum sixth grade reading level and estimated premorbid IQ
Able to state specific goals relevant to the intervention that participant would like to achieve
Able to participate in the computerized intervention, based on the judgment of the investigator
Psychiatric hospitalization within 8 weeks of random assignment
Adjustment to antipsychotic treatment within 4 weeks of random assignment
Currently taking an anticholinergic medication
DSM-IV diagnosis of alcohol or substance abuse (other than nicotine) within the last month or a DSM-IV diagnosis of alcohol or substance dependence (other than nicotine) within the last 6 months
History of mental retardation, pervasive developmental disorder, or other neurological disorder (such as a traumatic brain injury, epilepsy, or Parkinson 's disease)
All locations for NCT00930150
United States (9)
Yale University/Connecticut Mental Health Center
New Haven, Connecticut, United States, 06519
Atlanta, Georgia, United States, 30329
Medical College of Georgia
Augusta, Georgia, United States, 30912
University of Iowa Hospital
Iowa City, Iowa, United States, 52242
University of Massachusetts
Worcester, Massachusetts, United States, 01605
University of Minnesota School of Medicine
Minneapolis, Minnesota, United States, 55454
The University of North Carolina
Chapel Hill, North Carolina, United States, 27599-7160
Philadelphia VA Medical Center-116A
Philadelphia, Pennsylvania, United States, 19104
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
View full eligibility
Tris trial is registered with FDA with number: NCT00930150. The sponsor of the trial is National Institute of Mental Health (NIMH) and it is looking for 52 volunteers for the current phase.
Official trial title: Cognitive Remediation in the Schizophrenia Trials Network
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