To study the in vivo life span in healthy volunteers of red blood cells generated in vitro
from autologous peripheral stem cells. The study will be carried out in 4 phases :
- production in vitro of the equivalent of 1 ml of blood, i.e. 5x10e9 enucleated RBC from
mononuclear cells isolated from an HSC graft obtained from a healthy volunteers donor.
- labeling of these cRBC with 51 Cr
- reinjection of the autologous cRBC
- follow up of the receivers for a maximum 33 days to measure the half-life span of the