Obesity is characterized by continuous low-grade inflammation. This is an important link
between obesity and insulin resistance.
Results from the investigators' own group of in vitro and in vivo research on mice show that
Interleukin-1 is involved in the process of developing insulin resistance. Earlier it has
been shown that interleukin-1 receptor antagonist in human subjects improves glycemic
control. The investigators' hypothesis is that this is due to improved insulin sensitivity.