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More info
You can access this
clinical trial
if you have
Familial Adenomatous Polyposis
and you are
between 21 and 85
years old
-
The phase for this study is not defined.
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The purpose

Familial Adenomatous Polyposis (FAP) is an autosomal dominant disorder characterized by the formation of multiple adenomatous colorectal polyps usually in the teenage years. Virtually, all patients with FAP will develop colorectal cancer on average by the 5th decade of life if prophylactic surgery is not performed. Besides, these individuals must have lifelong cancer surveillance of the remaining colorectum or ileum. Use of nonsteroidal anti-inflammatory drug (NSAID), such as sulindac, or celecoxib, which selectively inhibits prostaglandin synthesis primarily via the inhibition of cyclogenase-2 (COX-2) have been shown to reduce the incidence and induce regression of adenomas in the rectum of patients with FAP. However, use of NSAIDs and COX-2 inhibitors is associated with significant comorbidity including renal and gastric toxicity and increased risk of vascular events. Therefore, identification of a chemopreventive agent that would have similar efficacy but less toxicity would enhance our ability to treat these patients. Therefore the following specific aim has been proposed:To determine in a randomized, double-blinded, placebo-controlled study the tolerability and efficacy of curcumin to regress intestinal adenomas by measuring duodenal and colorectal/ileal polyp number, and polyp size in patients with FAP.

Provided treatments

  • Drug: Calcumin (Curcumin)
  • Other: Risk Factor Questionnaire
  • Other: Blood samples
  • Other: Biopsies (Sigmoidoscopy)
  • Other: Biopsies (Upper endoscopy)
Tris trial is registered with FDA with number: NCT00927485. The sponsor of the trial is University of Puerto Rico and it is looking for 44 volunteers for the current phase.
Official trial title:
Use of Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)