The purpose of this study was to investigate a possible response to nalbuphine (Nubian) and
morphine with traditional Chinese herbs in healthy volunteers.
Drug: Morphine with Long dan xie gan tang
Drug: Nalbuphine with Long dan xie gan tang
Drug: Nubian with Long dan xie gan tang
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Full eligibility criteria for NCT00923000
Ages eligible for Study
20 Years to 40 Years
Genders eligible for Study
Accepts Healthy Volunteers
Normal healthy adult subjects between 20-40 years of age
Body weight within 80-120% of ideal body weight
Acceptable medical history, physical examination and clinical laboratory determinations
Recent history of drug or alcohol addiction or abuse
Donating greater than 150 ml of blood within two months prior to Period I
Taking any prescription medication or any nonprescription medication within 14 days prior to Period I doing
Receiving any investigational drug within 30 days prior to Period I dosing
Taking any drug known to induce or inhibit hepatic drug metabolism within 30 days prior to the beginning of the study
Any clinically significant diseases
History of allergic response to nalbuphine or related drugs and traditional Chinese herbs
All locations for NCT00923000
Tri-Service General Hospital
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View full eligibility
Tris trial is registered with FDA with number: NCT00923000. The sponsor of the trial is Tri-Service General Hospital and it is looking for 50 volunteers for the current phase.
Official trial title: Herb Drug Interaction of Traditional Chinese Herb and Commonly Used Drugs
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