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More info
You can access this
clinical trial
if you have
Advanced Gastric Cancer
and you are
between 18 and 74
years old
3
This is a trial in the final phase before the treatment is released on the market.
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The purpose

The urgent need for a new effective therapy with better safety profile for the metastatic gastric cancer patients and promising results observed so far in the studies with S-1 plus cisplatin combination in advanced gastric cancer (AGC) strongly warrants the comparison of a 3-weekly schedule to a 5-weekly schedule of S-1 plus cisplatin as a standard regimen in the first-line treatment for AGC patients. The objectives of this study are to compare a 3-weekly schedule to a 5-weekly schedule of S-1 plus Cisplatin combination in terms of efficacy, quality of life and safety in patients with previously untreated advanced or recurrent unresectable gastric cancer. Primary endpoint is progression-free survival. This is an open label, randomized, multi-center, non-inferiority/superiority (of 3-weekly regimen over 3-weekly regimen) hybrid study.

Provided treatments

  • Drug: S-1 and cisplatin
  • Drug: S-1 and cisplatin
Tris trial is registered with FDA with number: NCT00915382. The sponsor of the trial is Asan Medical Center and it is looking for 625 volunteers for the current phase.
Official trial title:
Phase III Trial of 3-weekly vs. 5-weekly Schedule of S-1 Plus Cisplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer.