This study will determine whether BOLD-fMRI can be used to probe hunger and satiety states in
healthy overweight or obese men and also whether fasted/fed fMRI signals can be modulated by
Drug: Comparator: sibutramine
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Full eligibility criteria for NCT00914212
Ages eligible for Study
18 Years to 45 Years
Genders eligible for Study
Accepts Healthy Volunteers
Subject is a male between 18 and 45 years of age
Subject has a body mass index (BMI) between 28 and 35 kg/m^2
Subject does not weigh more than 140 kg (309 lbs) at the screening visit
Subject is right-handed
Subject is a non-smoker
Subject is in generally good health
Subject has normal or corrected to normal vision
Subject works a night shift within 3 days of each treatment visit
Subject has permanent cosmetic or metallic objects in his body
Subject has attention deficit hyperactivity disorder (ADHD)
Subject has or had sleep apnea
Subject has a history of neurological disorders
Subject has a history of any clinically significant disease or condition
Subject is vegan or vegetarian
Subject has a history of eating disorders
Subject has had previous bariatric surgery
All locations for NCT00914212
View full eligibility
Tris trial is registered with FDA with number: NCT00914212. The sponsor of the trial is Merck Sharp & Dohme Corp. and it is looking for 15 volunteers for the current phase.
Official trial title: A Functional Magnetic Resonance Imaging (fMRI) Study of the Reproducibility and the Effect of Sibutramine During Fasted and Fed Conditions in Healthy Overweight and Obese Men
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