Osteoarthritis (OA) is a common degenerative condition of large weight-bearing joints, such
as the hip and knee, as well as small hand joints. Current interventions in patients with OA
are limited to symptomatic pain relief and later with total joint replacement (TJR). While
TJR improves function and pain, it does not fully restore function in most individuals. A key
factor of functional outcome is probably conditioning before and after TJR surgery. However,
this has not been studied conclusively in patients undergoing TKR surgery.
1. Primary endpoint: To study the effect of a pre-surgery neuromuscular PT compared to an
attention control program on lower extremity function measured by the Chair stands test
(observed function) and the KOOS score (reported function).
2. Secondary endpoints will be muscle strength, walking time and mobility.
The investigators hypothesize that patients undergoing pre-surgery PT will be significantly
quicker in performing the chair stands test and report a significant improvement in the KOOS
at 3 months after surgery compared to controls.
80 patients from a waiting list for unilateral TKR will be randomized to neuromuscular PT or
an attention control group intervention in a single-blinded randomized controlled trial.
Assessments will be at baseline, at 3 months after surgery and at 12 months after surgery.
The neuromuscular PT group will receive a minimum of 8 and a maximum of 24 training sessions;
all patients, including the control group, will receive 4 sessions of the Knee School.
Given the demographic change with an increase in the older segment of the population there
will be a rise in the absolute number of TKRs. It is therefore warranted to study pre-surgery
neuromuscular PT to help patients get the most out of their joint replacement.