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You can access this
clinical trial
if you have
and you are
between 18 and 35
years old
The phase for this study is not defined.
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The purpose

Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of ocular perfusion pressures. In the optic nerve head only few data are available. Large scale studies have shown that reduced ocular perfusion pressure is an important risk factor for the prevalence, the incidence and the progression of primary open angle glaucoma. Former studies that investigated ocular blood flow autoregulation only measured choroidal blood flow. For the optic nerve head only few data are available, although it seems likely that it underlies similar autoregulatory mechanisms. The primary goal of the present study is to gain more insight into these phenomena in humans. The present study aims to investigate the pressure/flow relationship as a measure for optic nerve head autoregulation during combined changes of intraocular pressure and arterial pressure. Intraocular pressure will be increased by the use of a suction cup technique, mean arterial pressure will be increased by squatting. During the whole procedure, optic nerve head blood flow will be measured continuously.

Provided treatments

  • Device: Laser Doppler Flowmetry
  • Device: Goldmann applanation tonometer
  • Other: squatting
  • Device: Suction cup
Tris trial is registered with FDA with number: NCT00912665. The sponsor of the trial is Medical University of Vienna and it is looking for 40 volunteers for the current phase.
Official trial title:
Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure