This trial is completed!
Search for a recruiting clinical trial for your condition
Your journey
1What's a trial
4Get in touch
More info
You can access this
clinical trial
if you have
Heart Disease or Vasodilation
and you are
between 18 and 85
years old
The phase for this study is not defined.
Show me locations

The purpose

The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. Apelin has the ability to cause blood vessels to relax, increasing their diameter and hence blood flow down the blood vessel. The researchers wish to investigate the hypothesis that an infusion of apelin will reduce the effects of angiotensin II, which is know to reduce the diameter of blood vessels.

Provided treatments

  • Drug: Angiotensin II
  • Drug: Noradrenaline infusion
Tris trial is registered with FDA with number: NCT00901745. The sponsor of the trial is University of Edinburgh and it is looking for 12 volunteers for the current phase.
Official trial title:
Investigating the Interaction of Apelin and Angiotensin II Peripheral Resistance Vessels in Vivo in Man