This is a small pilot study looking at the safety of giving combination chelation with Exjade
and Desferal to 15 patients. The hypothesis is that combination chelation is safe in
decreasing overall iron in patients with thalassemia.
Drug: Combo Chelation with Deferasirox (Exjade) and Desferal (DFO)
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Full eligibility criteria for NCT00901199
Ages eligible for Study
8 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Transfusion Dependent Thalassemia
If iron between 5-15 mg/g dry liver by SQUID, subject must have a documented endocrinopathy or cardiac finding
Older than 8 years
Participating on another interventional clinical trial
All locations for NCT00901199
United States (1)
Oakland, California, United States, 94609
View full eligibility
Tris trial is registered with FDA with number: NCT00901199. The sponsor of the trial is Children's Hospital & Research Center Oakland and it is looking for 22 volunteers for the current phase.
Official trial title: Safety of Deferasirox (ICL670) and Deferoxamine (Desferal or DFO) Combined Chelation Therapy in Patients With Transfusion Dependent Thalassemia and Iron Overload
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