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Intraperitoneal (IP) Autologous Therapeutic Tumor Vaccine AUT-OV-ALVAC-h.B7.1 Plus IP rIFN-gamma for Patients With Ovarian Cancer. A Pilot Study (NCT00004032)

Phase I trial to study the effectiveness of a tumor cell vaccine and interferon gamma in patients with refractory epithelial ovarian cancer. Vaccines made from a person's cancer cells may make the body build an immune response to and kill their tumor cells. Combining vaccine therapy with interferon gamma may be a more effective treatment for epithelial ovarian cancer
  • Biological: ALVAC-hB7.1
    Given IP
    • Biological: recombinant interferon gamma
      Given IP
      • Actimmune
      • gamma interferon
      • IFN-G
    • Other: laboratory biomarker analysis
      Correlative studies
      Ages eligible for Study
      Genders eligible for Study
      Accepts Healthy Volunteers

      I. Determine whether intraperitoneal (IP) injections of epithelial ovarian carcinoma cells infected with ALVAC-hB7.1 and IP interferon gamma have acceptable toxicity and produce any clinical responses in patients with refractory ovarian epithelial cancer.

      OUTLINE: This is a dose-escalation study of ALVAC-hB7.1 infected tumor cells.

      Patients receive ALVAC-hB7.1 infected tumor cells intraperitoneally (IP) on days 4, 11, and 18. Patients also receive interferon gamma IP on days 8, 10, 15, and 17. In the absence of disease progression, up to 6 courses of therapy may be given. If insufficient tumor cells are available to continue treatment with tumor cell derived vaccine, interferon gamma may be given alone. Cohorts of 3 to 6 patients receive escalating doses of ALVAC-hB7.1 infected tumor cells until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which no more than 2 of 6 patients experience dose-limiting toxicity.

      Patients are followed every 6 months until disease progression.

      PROJECTED ACCRUAL: A total of 12 patients will be accrued for this study.

      1 locations

      United States (1)
      • M D Anderson Cancer Center
        Not specified
        Houston, Texas, United States, 77030
      30 September, 1997
      21 January, 2013
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