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A Study to Determine the Ability of Folate Conjugates to Target Folate Receptors in Ovarian Cancer Tumors (NCT00003763)

RATIONALE: Diagnostic procedures using the drug radiolabeled folic acid and imaging may be effective in detecting ovarian cancer. PURPOSE: Diagnostic trial to study the effectiveness of radiolabeled folic acid plus imaging in detecting ovarian cancer.
  • Procedure: radionuclide imaging
    • Radiation: indium In 111 folic acid
      Ages eligible for Study
      18 Years to 120 Years
      Genders eligible for Study
      Accepts Healthy Volunteers
      OBJECTIVES: I. Evaluate the effectiveness of folic acid conjugated with indium In 111 to diagnose ovarian cancer and locate metastatic disease.

      OUTLINE: This is a diagnostic study. Patients receive an injection of folic acid conjugated with indium In 111. The patient then undergoes imaging studies at various time points (e.g., 1, 4, and 24 hours). Patients then undergo exploratory surgery, the results of which are then compared to the imaging studies.

      PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

      3 locations

      United States (3)
      • Indiana University Cancer Center
        Not specified
        Indianapolis, Indiana, United States, 46202-5265
      • Washington University - St. Louis
        Not specified
        St. Louis, Missouri, United States, 63110
      • University of Texas - MD Anderson Cancer Center
        Not specified
        Houston, Texas, United States, 77030
      31 December, 1998
      02 April, 2017
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