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Determinants and Within-subject Variability of Maximal Fat Oxidation During Exercise in Adults (NCT03029364)

The ability to upregulate fat oxidation at appropriate times such as during fasting, low to moderate intensity exercise and after a high fat meal, is an important marker of health and a determinant of optimal endurance performance. Maximal fat oxidation reportedly occurs at an exercise intensity between 45 - 65% of maximal oxygen capacity with large between-subject variability apparent. Numerous factors have been associated with maximal fat oxidation, but a large amount of variance remains unexplained. Additionally, the within-subject variability of maximal fat oxidation has not been systematically evaluated, but may partially account for the reported between-subject variability and thus, only once measured can determinants of maximal fat oxidation be more precisely determined. The investigators want to further explore determinants of and investigate the within-subject variability of fat oxidation during exercise in a wide range of 'healthy' and 'at risk of metabolic disease' adults. By investigating these processes this work will explore how nutrition and exercise can be optimised to improve health and weight loss.
  • Behavioral: Study Protocol
    Participants will complete two identical study protocols 7 - 14 days apart which includes: A study day (max. 2 hours) involving an incremental stage maximal cardiorespiratory fitness test Activity and Dietary monitoring for the immediate three days prior to study day Maintenance of habitual habits, dietary and physical activity behaviour patterns We are observing biological / health parameters in a group of individuals who perform an incremental-stage exercise test twice. The current study does not involve an intervention.
    Ages eligible for Study
    18 Years to 65 Years
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    Accepts Healthy Volunteers
    Inclusion Criteria:
    • be between 18 - 65 years of age
    • male or female
    • body mass index between 18.9 - 35 kg/m2
    • be able and willing to give informed oral and written consent
    • complete and meet the defined criteria of pre-study questionnaires and screens
    Exclusion Criteria:
    • Currently have or have a previous history of metabolic, cardio-pulmonary or musculoskeletal disease
    • BMI below 18.9 or above 35 kg/m2
    • Have plans to change lifestyle (diet and/or physical activity) during the study period ( 7 - 21 days)
    • Failure or do not agree to refrain from alcohol and strenuous exercise one day before or during trial days

    1 locations

    United Kingdom (1)
    • Department for Health, University of Bath
      not yet recruiting
      Bath, United Kingdom, BA2 7AY
    Status:
    not yet recruiting
    Type:
    Observational
    Phase:
    -
    Start:
    31 December, 2016
    Updated:
    18 January, 2017
    Participants:
    200
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