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The Incidence and Prognostic Significance of P16 INK4A/ P15 INK4B Gene Alterations in Children With Relapsed ALL Treated on CCG-1941 (NCT00003933)

National Cancer Institute (NCI)
RATIONALE: Diagnostic procedures, such as genetic testing, may improve the ability to detect acute lymphocytic leukemia and determine the extent of disease. PURPOSE: Diagnostic study to try to detect changes in the genes of children who have been treated for relapsed acute lymphocytic leukemia.
  • Other: laboratory biomarker analysis
    Ages eligible for Study
    up to 17 Years
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    No
    OBJECTIVES:

    - Determine the incidence of p16/p15 homozygous deletions and p15 promoter hypermethylation in acute lymphocytic leukemia cells of children treated on protocol CCG-1941.

    - Determine the prognostic importance of p16/p15 abnormalities in these children.

    - Determine the presence or absence of p16/p15 abnormalities in the dominant clone at diagnosis if present at relapse in these patients.

    OUTLINE: Frozen cells are obtained from samples collected on protocol CCG-1941. DNA is isolated and examined using Southern blot analysis to assay for deletions and promoter hypermethylation of p16 and/or p15.

    PROJECTED ACCRUAL: Approximately 100 samples will be obtained for this study.

    41 locations

    Status:
    completed
    Type:
    Interventional
    Phase:
    -
    Start:
    31 March, 1999
    Updated:
    05 August, 2014
    Participants:
    0
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