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Genetic Changes in Diffuse Aggressive Non-Hodgkin's Lymphoma (NCT00003863)

National Cancer Institute (NCI)
RATIONALE: Determination of genetic markers for aggressive non-Hodgkin's lymphoma may help identify patients with this disease and help predict the outcome of treatment. PURPOSE: Diagnostic study to determine the genetic markers in patients who have aggressive non-Hodgkin's lymphoma.
  • Genetic: comparative genomic hybridization
    • Genetic: cytogenetic analysis
      • Genetic: fluorescence in situ hybridization
        • Genetic: gene rearrangement analysis
          Ages eligible for Study
          18 Years and older
          Genders eligible for Study
          All
          Accepts Healthy Volunteers
          No
          OBJECTIVES:

          - Estimate the proportions of patients with diffuse aggressive non-Hodgkin's lymphoma who have rearrangements affecting the MYC, BCL2, and BCL6 genes (determined by fluorescent in situ hybridization), overtly amplified chromosomal regions, and nonrandom copy number changes of chromosomal regions (determined by comparative genomic hybridization).

          - Investigate the prognostic importance of these genetic markers by studying their relationships with clinical outcomes (e.g., response to therapy, failure-free survival, and overall survival) in these patients.

          - Investigate the interrelationships among these genetic and biological markers and their relationships with clinical features of the disease, such as disease site (nodal vs extranodal) and stage, in these patients.

          OUTLINE: This is a multicenter study.

          Tissue samples are obtained before treatment and at the time of documentation of refractory disease in patients who do not achieve complete remission after induction therapy or at the time of first relapse in patients who achieve a complete remission.

          Samples are examined for rearrangements in the MYC, BCL2, BCL6, and IGH genes using fluorescent in situ hybridization. DNA is examined by comparative genomic hybridization, which allows cytogenetic detection of losses and gains of chromosomal regions in tumor cells.

          Patients do not receive the results of the genetic testing and the results do not influence the type or duration of treatment.

          69 locations

          United States (69)
          • Northeast Alabama Regional Medical Center
            Anniston, Alabama, United States, 36202-2208
          • Rebecca and John Moores UCSD Cancer Center
            La Jolla, California, United States, 92093-0843
          • Naval Medical Center - San Diego
            San Diego, California, United States, 92134-3202
          • Veterans Affairs Medical Center - San Diego
            San Diego, California, United States, 92161
          • UCSF Comprehensive Cancer Center
            San Francisco, California, United States, 94115
          • Veterans Affairs Medical Center - San Francisco
            San Francisco, California, United States, 94121
          • CCOP - Christiana Care Health Services
            Newark, Delaware, United States, 19713
          • Lombardi Cancer Center at Georgetown University Medical Center
            Washington, District of Columbia, United States, 20007
          • Walter Reed Army Medical Center
            Washington, District of Columbia, United States, 20307-5001
          • Veterans Affairs Medical Center - Washington, DC
            Washington, District of Columbia, United States, 20422
          • Broward General Medical Center
            Fort Lauderdale, Florida, United States, 33316
          • Memorial Cancer Institute at Memorial Regional Hospital
            Hollywood, Florida, United States, 33021
          • CCOP - Mount Sinai Medical Center
            Miami Beach, Florida, United States, 33140
          • Veterans Affairs Medical Center - Chicago Westside Hospital
            Chicago, Illinois, United States, 60612
          • University of Chicago Cancer Research Center
            Chicago, Illinois, United States, 60637-1470
          • Louis A. Weiss Memorial Hospital
            Chicago, Illinois, United States, 60640
          • CCOP - Illinois Oncology Research Association
            Peoria, Illinois, United States, 61615-7828
          • West Suburban Center for Cancer Care
            River Forest, Illinois, United States, 60305
          • Fort Wayne Medical Oncology and Hematology, Incorporated
            Fort Wayne, Indiana, United States, 46885-5099
          • Holden Comprehensive Cancer Center at University of Iowa
            Iowa City, Iowa, United States, 52242-1009
          • Baptist Hospital East - Louisville
            Louisville, Kentucky, United States, 40207
          • Greenebaum Cancer Center at University of Maryland Medical Center
            Baltimore, Maryland, United States, 21201
          • Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
            Boston, Massachusetts, United States, 02115
          • UMASS Memorial Cancer Center - University Campus
            Worcester, Massachusetts, United States, 01655
          • Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
            Saint Joseph, Michigan, United States, 49085
          • Veterans Affairs Medical Center - Minneapolis
            Minneapolis, Minnesota, United States, 55417
          • University of Minnesota Cancer Center
            Minneapolis, Minnesota, United States, 55455
          • Veterans Affairs Medical Center - Columbia (Truman Memorial)
            Columbia, Missouri, United States, 65201
          • Ellis Fischel Cancer Center at University of Missouri - Columbia
            Columbia, Missouri, United States, 65203
          • CCOP - Kansas City
            Kansas City, Missouri, United States, 64131
          • Siteman Cancer Center at Barnes-Jewish Hospital
            Saint Louis, Missouri, United States, 63110
          • UNMC Eppley Cancer Center at the University of Nebraska Medical Center
            Omaha, Nebraska, United States, 68198-7680
          • CCOP - Southern Nevada Cancer Research Foundation
            Las Vegas, Nevada, United States, 89106
          • Veterans Affairs Medical Center - Las Vegas
            Las Vegas, Nevada, United States, 89106
          • New Hampshire Oncology-Hematology, PA - Hooksett
            Hooksett, New Hampshire, United States, 03106
          • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
            Lebanon, New Hampshire, United States, 03756-0002
          • Cancer Institute of New Jersey at the Cooper University Hospital
            Camden, New Jersey, United States, 08103
          • Veterans Affairs Medical Center - Buffalo
            Buffalo, New York, United States, 14215
          • CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
            East Syracuse, New York, United States, 13057
          • Elmhurst Hospital Center
            Elmhurst, New York, United States, 11373
          • Queens Cancer Center of Queens Hospital
            Jamaica, New York, United States, 11432
          • CCOP - North Shore University Hospital
            Manhasset, New York, United States, 11030
          • North Shore University Hospital
            Manhasset, New York, United States, 11030
          • Memorial Sloan-Kettering Cancer Center
            New York, New York, United States, 10021
          • New York Weill Cornell Cancer Center at Cornell University
            New York, New York, United States, 10021
          • Mount Sinai Medical Center
            New York, New York, United States, 10029
          • SUNY Upstate Medical University Hospital
            Syracuse, New York, United States, 13210
          • Veterans Affairs Medical Center - Syracuse
            Syracuse, New York, United States, 13210
          • Veterans Affairs Medical Center - Asheville
            Asheville, North Carolina, United States, 28805-9913
          • Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
            Chapel Hill, North Carolina, United States, 27599-7295
          • NorthEast Oncology Associates - Concord
            Concord, North Carolina, United States, 28025
          • Veterans Affairs Medical Center - Durham
            Durham, North Carolina, United States, 27705
          • Duke Comprehensive Cancer Center
            Durham, North Carolina, United States, 27710
          • Cape Fear Valley Medical Center
            Fayetteville, North Carolina, United States, 28302-2000
          • CCOP - Southeast Cancer Control Consortium
            Goldsboro, North Carolina, United States, 27534-9479
          • Lenoir Memorial Cancer Center
            Kinston, North Carolina, United States, 28503-1678
          • Comprehensive Cancer Center at Moore Regional Hospital
            Pinehurst, North Carolina, United States, 28374
          • Zimmer Cancer Center at New Hanover Regional Medical Center
            Wilmington, North Carolina, United States, 28402-9025
          • Comprehensive Cancer Center at Wake Forest University
            Winston-Salem, North Carolina, United States, 27157-1082
          • Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
            Columbus, Ohio, United States, 43210-1240
          • Oklahoma University Medical Center
            Oklahoma City, Oklahoma, United States, 73104
          • Miriam Hospital at Lifespan
            Providence, Rhode Island, United States, 02906
          • Veterans Affairs Medical Center - Dallas
            Dallas, Texas, United States, 75219
          • Vermont Cancer Center at University of Vermont
            Burlington, Vermont, United States, 05401-3498
          • Cancer Care Center at Martha Jefferson Hospital
            Charlottesville, Virginia, United States, 22902
          • Virginia Oncology Associates - Norfolk
            Norfolk, Virginia, United States, 23502
          • MBCCOP - Massey Cancer Center
            Richmond, Virginia, United States, 23298-0037
          • Oncology and Hematology Associates of Southwest Virginia, Incorporated - Roanoke
            Roanoke, Virginia, United States, 24014
          • St. Mary's Medical Center
            Huntington, West Virginia, United States, 25701
          Status:
          completed
          Type:
          Observational
          Phase:
          -
          Start:
          31 May, 1999
          Updated:
          30 June, 2016
          Participants:
          391
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