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The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer (NCT00003833)

National Cancer Institute (NCI)
NCIC Clinical Trials Group
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer. PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
  • Genetic: DNA stability analysis
    • Genetic: gene mapping
      Ages eligible for Study
      up to 69 Years
      Genders eligible for Study
      All
      Accepts Healthy Volunteers
      No
      OBJECTIVES:

      - Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer.

      - Determine if patient prognosis is dependent on the region of 8p AI.

      - Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p.

      - Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI.

      OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.

      59 locations

      Status:
      completed
      Type:
      Observational
      Phase:
      -
      Start:
      31 January, 1999
      Updated:
      11 July, 2016
      Participants:
      598
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