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Phase II Trial of Pre-Irradiation Chemotherapy With BCNU, Cisplatin and Oral Etoposide Combined With Radiation Therapy in the Treatment of Grade 3 Astrocytoma (Anaplastic Astrocytoma) (NCT00003621)

National Cancer Institute (NCI)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy plus radiation therapy in treating patients who have newly diagnosed anaplastic astrocytoma.
  • Drug: carmustine
    • Drug: cisplatin
      • Drug: etoposide
        • Radiation: radiation therapy
          Ages eligible for Study
          18 Years to 120 Years
          Genders eligible for Study
          All
          Accepts Healthy Volunteers
          No
          OBJECTIVES: I. Determine the efficacy of carmustine, cisplatin, and etoposide given prior to and during radiotherapy in patients with anaplastic astrocytoma. II. Assess the toxic effects associated with this regimen in these patients. III. Evaluate this regimen in terms of fatigue, depression, excessive daytime somnolence, and quality of life in these patients.

          OUTLINE: Patients receive carmustine IV over 1 hour on days 1-3, oral etoposide on days 1-21 and 29-49, and cisplatin IV over 1-2 hours on days 1-3 and 29-31. Treatment repeats every 8 weeks for 3 courses. Patients receive radiotherapy concurrently with the third course of chemotherapy. Quality of life is assessed every 4 months for 1 year, every 6 months for 4 years, and then annually for 5 years. Patients are followed every 3 months for 5 years and then annually thereafter.

          PROJECTED ACCRUAL: A total of 28 patients will be accrued for this study within 20 months.

          18 locations

          United States (18)
          • CCOP - Scottsdale Oncology Program
            Scottsdale, Arizona, United States, 85259-5404
          • CCOP - Illinois Oncology Research Association
            Peoria, Illinois, United States, 61602
          • CCOP - Cedar Rapids Oncology Project
            Cedar Rapids, Iowa, United States, 52403-1206
          • CCOP - Iowa Oncology Research Association
            Des Moines, Iowa, United States, 50309-1016
          • Siouxland Hematology-Oncology
            Sioux City, Iowa, United States, 51101-1733
          • CCOP - Wichita
            Wichita, Kansas, United States, 67214-3882
          • CCOP - Ochsner
            New Orleans, Louisiana, United States, 70121
          • CCOP - Duluth
            Duluth, Minnesota, United States, 55805
          • Mayo Clinic Cancer Center
            Rochester, Minnesota, United States, 55905
          • CentraCare Clinic
            Saint Cloud, Minnesota, United States, 56303
          • CCOP - Metro-Minnesota
            Saint Louis Park, Minnesota, United States, 55416
          • CCOP - Missouri Valley Cancer Consortium
            Omaha, Nebraska, United States, 68131
          • Quain & Ramstad Clinic, P.C.
            Bismarck, North Dakota, United States, 58501
          • Altru Health Systems
            Grand Forks, North Dakota, United States, 58201
          • CCOP - Toledo Community Hospital Oncology Program
            Toledo, Ohio, United States, 43623-3456
          • CCOP - Geisinger Clinic and Medical Center
            Danville, Pennsylvania, United States, 17822-2001
          • Rapid City Regional Hospital
            Rapid City, South Dakota, United States, 57709
          • CCOP - Sioux Community Cancer Consortium
            Sioux Falls, South Dakota, United States, 57105-1080
          Status:
          completed
          Type:
          Interventional
          Phase:
          Start:
          31 January, 1999
          Updated:
          11 July, 2016
          Participants:
          29
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