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A Phase I Study of Thrombopoietin (rhTPO) Plus G-CSF in Children Receiving Ifosfamide, Carboplatin, and Etoposide (I.C.E.) Chemotherapy for Recurrent or Refractory Solid Tumors (NCT00003597)

National Cancer Institute (NCI)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as thrombopoietin and G-CSF may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of chemotherapy. PURPOSE: Phase I trial to study the effectiveness of colony-stimulating factors in treating children who have recurrent or refractory solid tumors and who are receiving chemotherapy.
  • Biological: recombinant human thrombopoietin
    • RhTPO
    • BB-IND # 7431)
  • Drug: carboplatin
    • Paraplatin
    • CBDCA
    • NSC #241240
  • Drug: etoposide
    • VP-16
    • VePesid
    • NSC #141540
  • Drug: ifosfamide
    • IFX
    • IFOS
    • NSC #109724
    • IND #7887
  • Biological: G-CSF
    • GRANULOCYTE COLONY-STIMULATING FACTOR
    • r-metHuG-CSF
    • Filgrastim
    • Neupogen®
    • NSC #614629
Ages eligible for Study
1 Years to 21 Years
Genders eligible for Study
All
Accepts Healthy Volunteers
No
OBJECTIVES:

- Determine the pharmacokinetics and toxicities associated with the administration of recombinant human thrombopoietin in children with solid tumors receiving myelosuppressive chemotherapy with ifosfamide, carboplatin, and etoposide (ICE).

- Determine a safe dose of recombinant human thrombopoietin with filgrastim (G-CSF) in this patient population.

- Evaluate the time to platelet count recovery following chemotherapy in this patient population.

- Evaluate the depth and duration of neutropenia and thrombocytopenia and the number of platelet transfusion events in this patient population.

OUTLINE: This is a dose escalation study of recombinant human thrombopoietin.

All patients receive chemotherapy consisting of carboplatin IV over 60 minutes on days 0 and 1 and etoposide and ifosfamide IV over 60 minutes on days 0-4. Chemotherapy is continued in the absence of disease progression or unacceptable toxicity for a maximum of 6 courses every 21 days.

Cohorts of 3-6 patients each receive escalating doses of recombinant human thrombopoietin IV on days 4, 6, 8, 10, and 12 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which fewer than 2 patients experience dose limiting toxicity. After the MTD is determined an additional cohort of patients are treated at this dose level every other day on days 4-20. Patients receive filgrastim (G-CSF) subcutaneously beginning on day 5 and continuing until absolute neutrophil count is greater than 1000/mm3 for 2 consecutive days or day 33.

PROJECTED ACCRUAL: A total of 24 evaluable patients will be accrued for this study.

24 locations

Status:
completed
Type:
Interventional
Phase:
Start:
31 October, 1998
Updated:
22 July, 2014
Participants:
16
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