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Phase II Study of Hydroxyurea for Unresectable Meningioma (NCT00003590)

National Cancer Institute (NCI)
Eastern Cooperative Oncology Group
RATIONALE: Drugs used in chemotherapy such as hydroxyurea use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase II trial is studying how well hydroxyurea works in treating patients with unresectable benign meningioma.
  • Drug: hydroxyurea
    20 mg/kg/day PO
    Ages eligible for Study
    18 Years to 120 Years
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    No
    OBJECTIVES:

    - Determine the partial and complete response rates in patients with unresectable benign meningioma treated with hydroxyurea.

    - Assess the quantitative and qualitative toxic effects of this drug in this patient population.

    OUTLINE: Patients receive oral hydroxyurea twice daily for 2 years in the absence of disease progression or unacceptable toxicity.

    Patients are followed at 3 months, 6 months, and then every 6 months for 3 years.

    PROJECTED ACCRUAL: A total of 38 patients will be accrued for this study within 13 months.

    133 locations

    United States (133)
    • Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
      Fairbanks, Alaska, United States, 99701
    • St. Joseph's Hospital and Medical Center
      Phoenix, Arizona, United States, 85001-2071
    • CCOP - Western Regional, Arizona
      Phoenix, Arizona, United States, 85006-2726
    • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
      Little Rock, Arkansas, United States, 72205
    • City of Hope Comprehensive Cancer Center
      Duarte, California, United States, 91010-3000
    • CCOP - Bay Area Tumor Institute
      Oakland, California, United States, 94609-3305
    • University of California Davis Cancer Center
      Sacramento, California, United States, 95817
    • University of Colorado Cancer Center at University of Colorado Health Sciences Center
      Aurora, Colorado, United States, 80010
    • St. Anthony Central Hospital
      Denver, Colorado, United States, 80204-1335
    • Denver Health Medical Center
      Denver, Colorado, United States, 80204-4507
    • Veterans Affairs Medical Center - Denver
      Denver, Colorado, United States, 80220
    • Montrose Memorial Hospital Cancer Center
      Montrose, Colorado, United States, 81401
    • St. Anthony North Hospital
      Westminster, Colorado, United States, 80030
    • Exempla Lutheran Medical Center
      Wheat Ridge, Colorado, United States, 80033
    • M.D. Anderson Cancer Center - Orlando
      Orlando, Florida, United States, 32806-2134
    • North Idaho Cancer Center
      Coeur d'Alene, Idaho, United States, 83814
    • Rush-Copley Cancer Care Center
      Aurora, Illinois, United States, 60504-4206
    • St. Joseph Medical Center
      Bloomington, Illinois, United States, 61701
    • Graham Hospital
      Canton, Illinois, United States, 61520
    • Memorial Hospital
      Carthage, Illinois, United States, 62321
    • University of Illinois Medical Center
      Chicago, Illinois, United States, 60612
    • Veterans Affairs Medical Center - Chicago Westside Hospital
      Chicago, Illinois, United States, 60612
    • Eureka Hospital
      Eureka, Illinois, United States, 61530
    • Galesburg Clinic
      Galesburg, Illinois, United States, 61401
    • Galesburg Cottage Hospital
      Galesburg, Illinois, United States, 61401
    • InterCommunity Cancer Center of Western Illinois
      Galesburg, Illinois, United States, 61401
    • Mason District Hospital
      Havana, Illinois, United States, 62644
    • Hopedale Medical Complex
      Hopedale, Illinois, United States, 61747
    • Joliet Oncology Hematology Associates, Limited - West
      Joliet, Illinois, United States, 60435
    • Kewanee Hospital
      Kewanee, Illinois, United States, 61443
    • McDonough District Hospital
      Macomb, Illinois, United States, 61455
    • Edward Hospital Cancer Center
      Naperville, Illinois, United States, 60540
    • BroMenn Regional Medical Center
      Normal, Illinois, United States, 61761
    • Community Cancer Center
      Normal, Illinois, United States, 61761
    • Community Hospital of Ottawa
      Ottawa, Illinois, United States, 61350
    • Oncology Hematology Associates of Central Illinois - Ottawa
      Ottawa, Illinois, United States, 61350
    • Cancer Treatment Center at Pekin Hospital
      Pekin, Illinois, United States, 61554
    • Proctor Hospital
      Peoria, Illinois, United States, 61614
    • CCOP - Illinois Oncology Research Association
      Peoria, Illinois, United States, 61615-7828
    • Oncology/Hematology Associates of Central Illinois, P.C.
      Peoria, Illinois, United States, 61615-7828
    • Methodist Medical Center of Illinois
      Peoria, Illinois, United States, 61636
    • OSF St. Francis Medical Center
      Peoria, Illinois, United States, 61637
    • Illinois Valley Community Hospital
      Peru, Illinois, United States, 61354
    • Perry Memorial Hospital
      Princeton, Illinois, United States, 61356
    • St. Margaret's Hospital
      Spring Valley, Illinois, United States, 61362
    • Valley Cancer Center
      Spring Valley, Illinois, United States, 61362
    • Carle Cancer Center at Carle Foundation Hospital
      Urbana, Illinois, United States, 61801
    • Carle Clinic Association
      Urbana, Illinois, United States, 61801
    • Saint Anthony Memorial Health Centers
      Michigan City, Indiana, United States, 46360-4358
    • Siouxland Hematology-Oncology Associates
      Sioux City, Iowa, United States, 51101-1733
    • Mercy Medical Center - Sioux City
      Sioux City, Iowa, United States, 51101
    • St. Luke's Regional Medical Center
      Sioux City, Iowa, United States, 51104
    • Cancer Center of Kansas - Chanute
      Chanute, Kansas, United States, 66720
    • Cancer Center of Kansas, P.A. - El Dorado
      El Dorado, Kansas, United States, 67042
    • Cancer Center of Kansas - Kingman
      Kingman, Kansas, United States, 67068
    • Southwest Medical Center
      Liberal, Kansas, United States, 67901
    • Cancer Center of Kansas - Newton
      Newton, Kansas, United States, 67114
    • Cancer Center of Kansas - Ottawa
      Ottawa, Kansas, United States, 66067
    • Cancer Center of Kansas, P.A. - Parsons
      Parsons, Kansas, United States, 67357
    • Pratt Cancer Center of Kansas
      Pratt, Kansas, United States, 67124
    • Cancer Center of Kansas - Salina
      Salina, Kansas, United States, 67401
    • Salina Regional Health Center
      Salina, Kansas, United States, 67401
    • Cancer Center of Kansas - Wellington
      Wellington, Kansas, United States, 67152
    • Associates in Womens Health
      Wichita, Kansas, United States, 67203
    • Cancer Center of Kansas, P.A. - Wichita
      Wichita, Kansas, United States, 67214-3728
    • CCOP - Wichita
      Wichita, Kansas, United States, 67214-3882
    • Via Christi Cancer Center at Via Christi Regional Medical Center
      Wichita, Kansas, United States, 67214
    • Cancer Center of Kansas - Winfield
      Winfield, Kansas, United States, 67156
    • Mary Bird Perkins Cancer Center - Baton Rouge
      Baton Rouge, Louisiana, United States, 70809
    • Baton Rouge General Regional Cancer Center
      Baton Rouge, Louisiana, United States, 70821
    • Cancer Center at Medical Center of Louisiana - New Orleans
      New Orleans, Louisiana, United States, 70140-1015
    • DeCesaris Cancer Institute at Anne Arundel Medical Center
      Annapolis, Maryland, United States, 21401
    • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
      Baltimore, Maryland, United States, 21231
    • Josephine Ford Cancer Center at Henry Ford Health System
      Detroit, Michigan, United States, 48202
    • Fairview Ridges Hospital
      Burnsville, Minnesota, United States, 55337
    • Mercy Hospital
      Coon Rapids, Minnesota, United States, 55433
    • Fairview Southdale Hospital
      Edina, Minnesota, United States, 55435
    • Mercy and Unity Cancer Center at Mercy and Unity Hospitals
      Fridley, Minnesota, United States, 55432-2799
    • Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
      Minneapolis, Minnesota, United States, 55407
    • Hubert H. Humphrey Cancer Center at North Memorial Medical Center
      Robbinsdale, Minnesota, United States, 55422-2900
    • CCOP - Metro-Minnesota
      Saint Louis Park, Minnesota, United States, 55416
    • United Hospital
      Saint Paul, Minnesota, United States, 55102
    • Park Nicollet Clinic
      St. Louis Park, Minnesota, United States, 55416
    • Ridgeview Medical Center
      Waconia, Minnesota, United States, 55387
    • University of Mississippi Medical Center
      Jackson, Mississippi, United States, 39216-4505
    • Veterans Affairs Medical Center - Kansas City
      Kansas City, Missouri, United States, 64128
    • CCOP - Kansas City
      Kansas City, Missouri, United States, 64131
    • CCOP - Montana Cancer Consortium
      Billings, Montana, United States, 59101
    • Great Falls Clinic
      Great Falls, Montana, United States, 59403
    • Adena Regional Medical Center
      Chillicothe, Ohio, United States, 45601
    • Cleveland Clinic Taussig Cancer Center
      Cleveland, Ohio, United States, 44195-9001
    • CCOP - Columbus
      Columbus, Ohio, United States, 43206
    • Riverside Methodist Hospital Cancer Care
      Columbus, Ohio, United States, 43214-3998
    • Mount Carmel West Hospital
      Columbus, Ohio, United States, 43222
    • Doctors Hospital at Ohio Health
      Columbus, Ohio, United States, 43228
    • Grady Memorial Hospital
      Delaware, Ohio, United States, 43015
    • Community Oncology Group - Independence
      Independence, Ohio, United States, 44131
    • Fairfield Medical Center
      Lancaster, Ohio, United States, 43130
    • Strecker Cancer Center at Marietta Memorial Hospital
      Marietta, Ohio, United States, 45750-1635
    • Licking Memorial Cancer Care Program at Licking Memorial Hospital
      Newark, Ohio, United States, 43055-2899
    • Mercy Medical Center Oncology Unit
      Springfield, Ohio, United States, 45501
    • Community Hospital of Springfield and Clark County
      Springfield, Ohio, United States, 45505
    • Rose Ramer Cancer Clinic at Anderson Area Medical Center
      Anderson, South Carolina, United States, 29621
    • CCOP - Greenville
      Greenville, South Carolina, United States, 29615
    • Sioux Valley Hospital and University of South Dakota Medical Center
      Sioux Falls, South Dakota, United States, 57104
    • Avera McKennan Hospital and University Health Center
      Sioux Falls, South Dakota, United States, 57105-1080
    • Medical X-Ray Center
      Sioux Falls, South Dakota, United States, 57105
    • Brooke Army Medical Center
      Fort Sam Houston, Texas, United States, 78234-6200
    • Wilford Hall Medical Center
      Lackland Air Force Base, Texas, United States, 78236-5300
    • Center for Cancer Prevention and Care at Scott and White Clinic
      Temple, Texas, United States, 76508
    • American Fork Hospital
      American Fork, Utah, United States, 84003
    • Logan Regional Hospital
      Logan, Utah, United States, 84341
    • Cottonwood Hospital Medical Center
      Murray, Utah, United States, 84107
    • McKay-Dee Hospital Center
      Ogden, Utah, United States, 84403
    • Utah Valley Regional Medical Center - Provo
      Provo, Utah, United States, 84604
    • Dixie Regional Medical Center
      Saint George, Utah, United States, 84770
    • Huntsman Cancer Institute at University of Utah
      Salt Lake City, Utah, United States, 84112-5550
    • LDS Hospital
      Salt Lake City, Utah, United States, 84143
    • Grays Harbor Community Hospital
      Aberdeen, Washington, United States, 98520
    • Auburn Regional Center for Cancer Care at Auburn Regional Medical Center
      Auburn, Washington, United States, 98001-4908
    • St. Francis Hospital
      Federal Way, Washington, United States, 98003
    • Cascade Cancer Center at Evergreen Hospital Medical Center
      Kirkland, Washington, United States, 98034-3013
    • St. Clare Hospital
      Lakewood, Washington, United States, 98499-0998
    • Capital Medical Center
      Olympia, Washington, United States, 98502
    • Providence St. Peter Hospital Regional Cancer Center
      Olympia, Washington, United States, 98506
    • Olympic Medical Center
      Port Angeles, Washington, United States, 98362
    • Good Samaritan Cancer Center
      Puyallup, Washington, United States, 98371
    • Valley Medical Center
      Renton, Washington, United States, 98055
    • CCOP - Virginia Mason Research Center
      Seattle, Washington, United States, 98101
    • CCOP - Northwest
      Tacoma, Washington, United States, 98405-0986
    • St. Joseph Medical Center at Franciscan Health System
      Tacoma, Washington, United States, 98405-3004
    • Allenmore Hospital
      Tacoma, Washington, United States, 98411-0414
    • Camden-Clark Memorial Hospital
      Parkersburg, West Virginia, United States, 26102
    Participant Flow: Overall Study
    Hydroxyurea
    Serious Adverse Events
    Hydroxyurea
    Other Adverse Events
    Hydroxyurea
    Status:
    completed
    Type:
    Interventional
    Phase:
    Start:
    31 October, 1998
    Updated:
    19 April, 2016
    Participants:
    29
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