The objective of this study is to quantify salivary oxidative stress biomarkers in patients
with temporomandibular disorders and to quantify recently isolated endogenous peptide
opiorphin in saliva of these patients. As chronic exposure to stress may cause hyperalgesia
as a result of the stress response in the hypothalamic-pituitary-adrenal axis, aim is to test
this as an underlying mechanism by correlating opiorphin and oxidative stress markers to
salivary cortisol levels. The aim is to assess the association of oxidative stress salivary
biomarkers with muscle and joint pain and to measure opiorphin, a potential biomarker of
different pathological states.