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More info
You can access this
clinical trial
if you have
Temporomandibular Disorders
and you are
between 18 and 75
years old
The phase for this study is not defined.
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The purpose

The objective of this study is to quantify salivary oxidative stress biomarkers in patients with temporomandibular disorders and to quantify recently isolated endogenous peptide opiorphin in saliva of these patients. As chronic exposure to stress may cause hyperalgesia as a result of the stress response in the hypothalamic-pituitary-adrenal axis, aim is to test this as an underlying mechanism by correlating opiorphin and oxidative stress markers to salivary cortisol levels. The aim is to assess the association of oxidative stress salivary biomarkers with muscle and joint pain and to measure opiorphin, a potential biomarker of different pathological states.

Provided treatments

  • Device: stabilization splint
  • Drug: Placebo Oral Tablet
  • Device: placebo splint
  • : Vitamin C

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03029494. The sponsor of the trial is Croatian Science Foundation and it is looking for 80 volunteers for the current phase.
Official trial title:
The Role of Oxidative Stress and Opiorphin in Temporomandibular Disorders