Rhabdomyolysis is a common condition in the UAA. Support is heterogeneous, it is in most
cases a mass hyperhydration. The idea is to initially with an EPP simultaneously screened for
the most affected by this disease and aggravating factors population, associated
The rhabdomyolysis prognosis depends mainly on the etiology and associated comorbidities.
- Acute renal failure and hyperkalemia are the major complications that worsen the
- In most cases, acute renal failure is reversible. Acute renal failure caused by renal
vasoconstriction with ischemia, precipitation of myoglobin in the tubules and direct
cytotoxic action of myoglobin.
If the prime mover of rhabdomyolysis is ischemia (or hypoxia) cell, we now know that the
tissue damage is greatly aggravated during muscle reperfusion, creating ischemia-reperfusion.
Reperfusion will not only cause the release into the bloodstream of the cell contents
myocytes but also an increase in necrotic areas. Indeed, the massive arrival of oxygen at the
myocyte will cause significant production of free radicals, increasing their toxic effects.
Predictive factors of acute renal failure is creatinine and urea. The urine alkalinisation by
bicarbonates is questionable oral alkalizing seems to be an alternative when possible (oral
alkaline solution) but not used to this day.
The track N-acetyl cysteine as an antioxidant that can possibly have an effect on release of
the free radicals during reperfusion by decreasing their toxicity is still not considered