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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Head and Neck Squamous Cell Carcinoma
and you are
between 18 and 70
years old
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

Concomitant chemoradiotherapy improves overall survival in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) compared to radiotherapy alone. Cisplatin 100 mg/m2 at day 1, 22 and 43 is widely used but results in considerable acute and late toxicity. Three cycles of carboplatin plus 5-fluorouracil (5-FU) is an accepted alternative but both chemotherapy regimens have not been compared prospectively. The aim of this study is to compare tolerability, efficacy, toxicity and quality of life in patients with LA-HNSCC treated with concomitant cisplatin and carboplatin plus 5-FU.

Provided treatments

  • Drug: cisplatin
  • Drug: carboplatin
  • Drug: 5-FU

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02778191. The sponsor of the trial is University Medical Center Groningen and it is looking for 413 volunteers for the current phase.
Official trial title:
Comparison of Concomitant Cisplatin Versus Carboplatin and 5-fluorouracil With Radiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma