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More info
You can access this
clinical trial
if you have
Head and Neck Squamous Cell Carcinoma
and you are
between 18 and 70
years old
-
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

Concomitant chemoradiotherapy improves overall survival in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) compared to radiotherapy alone. Cisplatin 100 mg/m2 at day 1, 22 and 43 is widely used but results in considerable acute and late toxicity. Three cycles of carboplatin plus 5-fluorouracil (5-FU) is an accepted alternative but both chemotherapy regimens have not been compared prospectively. The aim of this study is to compare tolerability, efficacy, toxicity and quality of life in patients with LA-HNSCC treated with concomitant cisplatin and carboplatin plus 5-FU.

Provided treatments

  • Drug: cisplatin
  • Drug: carboplatin
  • Drug: 5-FU
Tris trial is registered with FDA with number: NCT02778191. The sponsor of the trial is University Medical Center Groningen and it is looking for 413 volunteers for the current phase.
Official trial title:
Comparison of Concomitant Cisplatin Versus Carboplatin and 5-fluorouracil With Radiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma