Postoperative nausea and vomiting (PONV) is a displeasing experience that distresses surgical
patients during the first 24 hours after a surgical procedure. The incidence of postoperative
nausea occurs in about 50%, the incidence of postoperative vomiting is about 30%, and in
high-risk patients, the PONV rate could be as high as 80%. Therefore, the study design of
this single arm, non-randomized, pilot study assessed the efficacy and safety profile of a
triple therapy combination with palonosetron, dexamethasone and promethazine to prevent PONV
in patients undergoing craniotomies under general anesthesia.