The study is a phase 2a, single blind, randomized, placebo controlled, study evaluating the
safety, anti-viral activity, and pharmacokinetics (PK) following multiple doses of
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Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT02631096
Ages eligible for Study
18 Years to 70 Years
Genders eligible for Study
Accepts Healthy Volunteers
Documented chronic HBV infection for ≥12 months prior to Screening Visit.
Quantitative HBsAg ≥1000 IU/mL at the Screening Visit.
Subjects currently receiving entecavir and/or tenofovir for ≥12 months and HBV DNA undetectable. Key
Known co-infection with HIV, hepatitis C virus, and hepatitis D virus.
Receiving or planning to receive systemic immunosuppressive medications during the study or ≤2 months prior to the first dose of study treatment.
Receiving or planning to receive interferon during the study or ≤12 months prior to the first dose of study treatment.
Significant immunosuppression from, but not limited to immunodeficiency conditions such as common variable hypogammaglobulinemia.
Clinical diagnosis of substance abuse with alcohol, narcotics, or cocaine ≤12 months prior to the Screening Visit.
Any known pre-existing medical or psychiatric condition that could interfere with the subject's ability to provide informed consent or participate in study conduct, or that may confound study findings.
All locations for NCT02631096
Monash Health, Gastroenterology and Hepatology
Clayton, Victoria, Australia, 3168
The Alfred, Gastroenterology and Hepatology
Melbourne, Victoria, Australia, 3004
Linear Clinical Research Ltd
Nedlands, Western Australia, Australia, 6009
New Zealand (1)
Auckland Clinical Studies Ltd
Auckland, New Zealand, 1010
New Zealand (1)
Waikato Hospital, Gastroenterology
Hamilton, New Zealand, 3240
View full eligibility
Tris trial is registered with FDA with number: NCT02631096. The sponsor of the trial is Arbutus Biopharma Corporation and it is looking for 36 volunteers for the current phase.
Official trial title: A Phase 2a Single-Blind, Randomized, Placebo-Controlled Study Evaluating the Safety, Anti Viral Activity, and Pharmacokinetics of ARB-001467 in Non Cirrhotic, HBeAg Negative and Positive Subjects With Chronic HBV Infection Receiving Nucleos(t)Ide Analogue Therapy
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