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More info
You can access this
clinical trial
if you have
Post-operative Nausea or Post-operative Vomiting
and you are
under 17
years old
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

The purpose of this study is to evaluate the pharmacokinetics (PK), safety, and tolerability of aprepitant for the prevention of post-operative nausea and vomiting (PONV) in pediatric participants. Post-operative aprepitant plasma concentrations will be evaluated with a non-compartmental analysis (NCA) at each dose and for each age cohort. Full PK profiles analyzed using population PK modeling and simulation will be described in a separate report.

Provided treatments

  • Drug: Aprepitant
  • Drug: Placebo to Aprepitant
  • Drug: Ondansetron
  • Drug: Placebo to match ondansetron

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01732458. The sponsor of the trial is Merck Sharp & Dohme Corp. and it is looking for 229 volunteers for the current phase.
Official trial title:
A Phase IIb, Partially-Blinded, Randomized, Active Comparator-Controlled Study to Evaluate the Pharmacokinetics/Pharmacodynamics, Safety, and Tolerability of Aprepitant in Pediatric Patients for the Prevention of Post Operative Nausea and Vomiting