The purpose of this study is to evaluate the pharmacokinetics (PK), safety, and tolerability
of aprepitant for the prevention of post-operative nausea and vomiting (PONV) in pediatric
Post-operative aprepitant plasma concentrations will be evaluated with a non-compartmental
analysis (NCA) at each dose and for each age cohort. Full PK profiles analyzed using
population PK modeling and simulation will be described in a separate report.