Rheumatoid arthritis(RA) with a high incidence and high morbidity, the pathogenesis has not
been fully elucidated. Fibroblast-like synovial cells excessive proliferation and synovial
angiogenesis is the most important cause of RA synovitis and joint destruction. Our study was
to find the role of Sonic Hedgehog(SHH) pathway in regulating proliferation of
fibroblast-like synovial cells and modulating excess angiogenesis of synovial tissue.