The purpose of this study is determine if you have too much fat in your body that it will
decrease the conversion of food energy into energy that your body can use.
Other: Lipid infusion and muscle biopsies
We will connect you to the doctor responsible for this trial and help you get more information.
Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT01724515
Ages eligible for Study
21 Years to 55 Years
Genders eligible for Study
Accepts Healthy Volunteers
Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
Subjects may be of either sex with age as described in each protocol. Female subjects must be non-lactating and will be eligible only if they have a negative pregnancy test throughout the study period.
Subjects must range in age as described in each specific protocol.
Subjects must have the following laboratory values:
Hematocrit ≥ 35 vol%
Serum creatinine ≤ 1.6 mg/dl
Aspartate Aminotransferase (AST) (SGOT) < 2 times upper limit of normal
Alanine Aminotransferase (ALT) (SGPT) < 2 times upper limit of normal
Alkaline phosphatase < 2 times upper limit of normal
Triglycerides < 150 mg/dl.
Prothrombin Time (PT) 11.7 - 14.3 seconds (during Intralipid/heparin infusion, PT will be determined to insure that it is < 1.5-2.0 times the normal value.)
Partial Thromboplastin Time (PTT) 23.0-37.0 seconds.
Subjects must not be receiving any of the following medications: thiazide or furosemide diuretics, beta-blockers, or other chronic medications with known adverse effects on glucose tolerance levels unless the patient has been on a stable dose of such agents for the past three months before entry into the study. Subjects may be taking a stable dose of estrogens or other hormonal replacement therapy, if the subject has been on these agents for the prior three months. Subjects taking systemic glucocorticoids are excluded.
Subjects with a history of clinically significant heart disease (New York Heart Classification greater than grade II; more than non-specific ST-T wave changes on the EKG), peripheral vascular disease (history of claudication), or pulmonary disease
(dyspnea on exertion of one flight or less; abnormal breath sounds on auscultation) will not be studied.
Some people want to consult their doctor before considering participation in a clinical trial. This is absolutely normal as your doctor should know your medical history and should be able to advise you. If you want you can easily share the information for this trial with your doctor by clicking on the button below.